Open Research Studies at the Penn Memory Center


The purpose the EmPCAD study is to develop inexpensive, noninvasive cognitive screening tools which help to detect the earliest signs of Alzheimer’s disease pathology in people before they have symptoms of the disease. This study will evaluate several memory tests in cognitively normal older adults to determine if they are sensitive to evidence of Alzheimer’s disease brain changes based on cerebrospinal fluid (CSF) analysis.

Individuals 60-89 years of age who are cognitively normal may be eligible, and no study partner is required.

The EmPCAD study seeks participants already enrolled in the Penn Memory Center longitudinal cohort of the NACC study or participants who have completed equivalent testing.


Download a one-page overview of this study including contact information



Metformin is a Phase II study that examines the cognitive effects of the diabetes drug Metformin on non-diabetic individuals.

Those with mild cognitive impairment (MCI) or early Alzheimer’s disease may be eligible. The study consists of one baseline visit, five in-clinic visits (one per month for five consecutive months), and twelve weekly phone calls.

Download a one-page overview of the study including contact information


The Merck BACE 1 study is a Phase II study testing the safety, tolerability, and cognitive effects of the Merck BACE inhibitor drug.

Individuals 55-85 years of age with a diagnosis of mild to moderate Alzheimer’s disease may be eligible. The study includes one baseline visit, 10 in-clinic visits, and 7 phone calls.

Download a one-page overview of the study including contact information

Welcome to Penn Memory Center

2014Brain Health Fair graphic



Brain Health Fair



2014 Brain Health Fair in Philadelphia on

Saturday, April 26, 2014!

Patients, families, caregivers and members of the public are invited to stop by Penn Medicine’s booths at the Brain Health Fair on April 26 at the Philadelphia Convention Center, hosted by the American Brain Foundation as part of the 2014 American Academy of Neurology Annual Meeting. Penn Medicine doctors, nurses and social workers will be sharing the latest on stroke prevention, brain tumor clinical trials, Parkinson’s, Alzheimer’s, concussions, Multiple Sclerosis and more! Register for the free event online at


The Penn Memory Center is now registering participants for our Spring Journaling Group:

Thursdays April 24 – May 29, 2014

Our spring journaling course begins on April 24 and will focus on the emotional challenges of “decluttering.” Classes will be held on Thursdays, April 24 through May 29, from 10am – 12pm and will be facilitated by Michelina Mucci-Deming, M.S.W., a Normal Control research participant in the PMC longitudinal NACC study.

Ms. Mucci-Deming is a certified instructor in the Journal to the Self ® method of therapeutic writing founded by Kathleen Adams, Director of the Center for Journal Therapy.  Ms. Mucci-Deming recently retired from her practice in social work with the purpose of connecting the power and benefits of journal writing to a wider audience.

This journaling course is free to the PMC network and will be held at Ralston House, 3615 Chestnut Street, Room 346.

For more information and to register, please contact Barbara Overholser at or 215-898-8997.


Do you have a passion, talent, or skill that you would like to share with others?

Research tells us that cognitive stimulation and social engagement are key components to successful aging. The Penn Memory Center is pleased to provide a platform for our patients and community to come together and learn from one another. If you would like to volunteer to lead a book club or a discussion group, teach knitting, lead a yoga class, or share another skill with others at the Penn Memory Center, we are happy to host, promote and provide some administrative assistance to transform your interest into action.

Interested volunteers should contact Felicia Greenfield at 215-614-1828 or

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