Open Research Studies at the Penn Memory Center

toyama handout

The Toyama study will investigate the safety, tolerability and cognitive effects of the T-817MA drug on individuals with mild to moderate Alzheimer’s disease. This drug is not FDA approved and is investigational. Individuals 55 -85 years of age with a diagnosis of probable AD and who have been taking donepezil (Aricept) for at least 6 months may be eligible.

Download a one-page overview of this study including contact information.

AVID image

The purpose of the AVID study is to evaluate the safety and imaging characteristics of an investigational PET imaging agent that binds to a protein called tau. Being able to measure tau protein is of considerable importance for tracking brain changes associated with Alzheimer’s disease.

This new PET tracer has potential application as a marker for assessing disease severity and may be useful in selecting patients for therapy and for monitoring disease progression.

Individuals at least 50 years of age with Mild Cognitive Impairment or Alzheimer’s disease may be eligible for this study.

Download a one-page overview of this study including contact information (for Individuals with Mild Cognitive Impairment or Alzheimer’s disease).



Merck BACE 1 MCI Handoutimage

The Merck BACE-1 Study is a Phase III study for patients with Mild Cognitive Impairment testing the safety, tolerability and cognitive effects of the Merck BACE inhibitor drug. This study is for individuals 50-85 years of age with a diagnosis of mild cognitive impairment.

This drug is not FDA approved and is investigational. As a BACE inhibitor, the drug inhibits the enzyme that produces beta amyloid plaques, deposits of which accumulate in the brains of patients with Alzheimer’s disease. The study will assess the effects of the drug on cognition and the ability to perform everyday activities.

Participants must have a reliable study partner: a spouse, relative, or friend who knows the participant well and sees him or her often, who will attend all study visits, and who will provide information about the participant during the study.

Download a one-page overview of this study including contact information

Welcome to Penn Memory Center

Cognitive Fitness is Enrolling Now

The Cognitive Fitness program is designed for people with concerns about their cognitive health, or for those with a diagnosis of mild cognitive impairment (MCI) who are facing new challenges related to thinking, learning and remembering. We offer a core 8-week course, and are pleased to announce additional workshops and social groups.

To RSVP, register or receive more information, contact Scott M. Reid, Cognitive Fitness Facilitator, at 215-662-6734 or  Download a flyer here.

Winter Workshops
Open to all – $40 per class or $70 for both
Location: Ralston House, 3615 Chestnut Street, Philadelphia

Communication Workshop
Learn effective communication skills to improve/enhance your listening
and communication.
Wednesday, January 28th
10AM – 3PM

Stress Management Workshop
Learn how to reduce stress using mindfulness meditation and
other techniques known to help people “respond” rather than “react” to stress.
Wednesday, February 25th
10AM – 3PM
Fourth Friday Social Groups
Cognitive Fitness Alumni Only – Free

Reconnect with friends made in your Cognitive Fitness cohort,
and meet others who have completed the program in a different class.
This is a great way to stay connected and socially engaged.

Location: Perelman Center for Advanced Medicine
3400 Civic Center Boulevard, Philadelphia
10:30 AM – 12:00PM

January 23rd  February 27th  March 27th  April 24th  May 22nd  June 26th
8-Week Spring Session
March 23 – May 15

This is our core Cognitive Fitness class that meets twice weekly for 8 weeks.
Tuition is $950. Save $150 by signing up for a screening and registering before February 15, 2015!

Available in West Philadelphia and Valley Forge

The Penn Memory Center Choral Group is Now Enrolling for Winter/Spring 2015

After two exciting and successful sessions, we’re eager to start singing again. Past participants in the Penn Memory Center Choral Group had a rewarding experience, and you can too. The group is led by Darina Petrovsky, a classically trained musician and doctoral nursing student at the University of Pennsylvania where she investigates the impact of singing on language and memory in older adults.

The Penn Memory Center Choral Group will meet Wednesdays, 2:00 pm.- 3:00 p.m., at Ralston House, 3615 Chestnut Street, Philadelphia, starting on February 4, 2015.

To register or learn more information about the program, please contact Barbara Overholser at or 215-573-9736.

To download a flyer, click here.


The A4 Study is Now Enrolling at the Penn Memory Center

If you are a healthy older adult with normal memory, now is the time to join the fight to prevent Alzheimer’s disease.

The A4 study is a historic clinical trial for older individuals who may be at risk for Alzheimer’s disease (AD). The study aims to prevent the memory loss associated with Alzheimer’s disease (AD).

You can read more about the study and the eligibility requirements at the A4 Study website.


Do you have a passion, talent, or skill that you would like to share with others?

Research tells us that cognitive stimulation and social engagement are key components to successful aging. The Penn Memory Center is pleased to provide a platform for our patients and community to come together and learn from one another. If you would like to volunteer to lead a book club or a discussion group, teach knitting, lead a yoga class, or share another skill with others at the Penn Memory Center, we are happy to host, promote and provide some administrative assistance to transform your interest into action.

Interested volunteers should contact Felicia Greenfield at 215-614-1828 or

News and Events

On February, 23, 2015, the Penn Memory Center at the Perelman Center for Advanced Medicine will be moving down the
Read More

Join us on May 5, 11:30am – 5:00pm, for the Institute on Aging’s Sylvan M. Cohen 2015 Annual Retreat:  ”Aging
Read More

Philly Voice recently published a feature about ARTZ Philadelphia’s program to connect dementia patients with art, and its partnership with
Read More

A New York Times article looks at the debate about whether people who develop dementia can use “voluntarily stopping eating
Read More

Philadelphia Inquirer reporter Stacey Burling interviewed Penn Memory Center research participants and clinicians in her article about the Anti-Amyloid Treatment
Read More

Penn Memory Center in the Community

Click here to find out about the important work the Penn Memory Center is doing in the Philadelphia community.

 PMC in community

What does it mean to be a caregiver?

Click here to listen to the stories of caregivers from the PMC community.

I am a Caregiver


Questions? Please contact Tigist Hailu, Coordinator for Diversity in Research, at or 215-573-6095.