Open Research Studies at the Penn Memory Center

toyama handout

The Toyama study will investigate the safety, tolerability and cognitive effects of the T-817MA drug on individuals with mild to moderate Alzheimer’s disease. This drug is not FDA approved and is investigational. Individuals 55 -85 years of age with a diagnosis of probable AD and who have been taking donepezil (Aricept) for at least 6 months may be eligible.

Download a one-page overview of this study including contact information.

AVID image

The purpose of the AVID study is to evaluate the safety and imaging characteristics of an investigational PET imaging agent that binds to a protein called tau. Being able to measure tau protein is of considerable importance for tracking brain changes associated with Alzheimer’s disease.

This new PET tracer has potential application as a marker for assessing disease severity and may be useful in selecting patients for therapy and for monitoring disease progression.

Individuals at least 50 years of age with Mild Cognitive Impairment, Alzheimer’s disease or normal cognition may be eligible for this study.

Download a one-page overview of this study including contact information (for Individuals with Mild Cognitive Impairment or Alzheimer’s disease).

Download a one-page overview of this study including contact information (for Individuals normal cognition).

 

Merck BACE 1 MCI Handoutimage

The Merck BACE-1 Study is a Phase III study for patients with Mild Cognitive Impairment testing the safety, tolerability and cognitive effects of the Merck BACE inhibitor drug. This study is for individuals 50-85 years of age with a diagnosis of mild cognitive impairment.

This drug is not FDA approved and is investigational. As a BACE inhibitor, the drug inhibits the enzyme that produces beta amyloid plaques, deposits of which accumulate in the brains of patients with Alzheimer’s disease. The study will assess the effects of the drug on cognition and the ability to perform everyday activities.

Participants must have a reliable study partner: a spouse, relative, or friend who knows the participant well and sees him or her often, who will attend all study visits, and who will provide information about the participant during the study.

Download a one-page overview of this study including contact information

Welcome to Penn Memory Center

 

The A4 Study is Now Enrolling at the Penn Memory Center

If you are a healthy older adult with normal memory, now is the time to join the fight to prevent Alzheimer’s disease.

The A4 study is a historic clinical trial for older individuals who may be at risk for Alzheimer’s disease (AD). The study aims to prevent the memory loss associated with Alzheimer’s disease (AD).

You can read more about the study and the eligibility requirements at the A4 Study website.

_______________________________________________________________________________________

Do you have a passion, talent, or skill that you would like to share with others?

Research tells us that cognitive stimulation and social engagement are key components to successful aging. The Penn Memory Center is pleased to provide a platform for our patients and community to come together and learn from one another. If you would like to volunteer to lead a book club or a discussion group, teach knitting, lead a yoga class, or share another skill with others at the Penn Memory Center, we are happy to host, promote and provide some administrative assistance to transform your interest into action.

Interested volunteers should contact Felicia Greenfield at 215-614-1828 or felicia.greenfield@uphs.upenn.edu.



News and Events

Congress has created a formal process to ensure that scientific judgment will guide them in future Alzheimer’s research funding. The 
Read More


Please join the university community in commemorating Dr. Martin Luther King Jr.’s legacy on January 15, 2015 at noon in the
Read More


Jason Karlawish, MD, Associate Director of the Penn Memory Center visited the Rochester, NY studios of Second Opinion for an
Read More


David Satcher, MD, former director of the CDC and former Surgeon General, writes in The Hill, “Our nation is facing
Read More


What happens when you bring two medical ethicists together to discuss what it means to age with quality of life?
Read More


Penn Memory Center in the Community

Click here to find out about the important work the Penn Memory Center is doing in the Philadelphia community.

 PMC in community

What does it mean to be a caregiver?

Click here to listen to the stories of caregivers from the PMC community.

I am a Caregiver

 

Questions? Please contact Tigist Hailu, Coordinator for Diversity in Research, at tigist.hailu@uphs.upenn.edu or 215-573-6095.