Open Research Studies at the Penn Memory Center


The purpose of the Aging Brain & Cognition (ABC) study is to learn about how the aging brain makes quick decisions. Individuals above the age of 60 with a diagnosis of Alzheimer’s Disease (AD), Mild Cognitive Impairment (MCI), or normal controls, may be eligible to participate. Study activity includes a visit to the clinic at the Penn Memory Center for one 1-hour appointment and completion of several computerized, puzzle-like problems that will take about 1 hour.

Download a one-page overview of this study including contact information.

toyama handout

The Toyama study will investigate the safety, tolerability and cognitive effects of the T-817MA drug on individuals with mild to moderate Alzheimer’s disease. This drug is not FDA approved and is investigational. Individuals 55 -85 years of age with a diagnosis of probable AD and who have been taking donepezil (Aricept) for at least 6 months may be eligible.

Download a one-page overview of this study including contact information.

AVID image

The purpose of the AVID study is to evaluate the safety and imaging characteristics of an investigational PET imaging agent that binds to a protein called tau. Being able to measure tau protein is of considerable importance for tracking brain changes associated with Alzheimer’s disease.

This new PET tracer has potential application as a marker for assessing disease severity and may be useful in selecting patients for therapy and for monitoring disease progression.

Individuals at least 50 years of age with Mild Cognitive Impairment or Alzheimer’s disease may be eligible for this study.

Download a one-page overview of this study including contact information (for Individuals with Mild Cognitive Impairment or Alzheimer’s disease).



Welcome to Penn Memory Center

Cognitive Fitness is Enrolling Now

The Cognitive Fitness program is designed for people with concerns about their cognitive health, or for those with a diagnosis of mild cognitive impairment (MCI) who are facing new challenges related to thinking, learning and remembering. We offer a core 8-week course, and are pleased to announce additional workshops and social groups.

To RSVP, register or receive more information, contact Scott M. Reid, Cognitive Fitness Facilitator, at 215-662-6734 or  Download a flyer here.
Fourth Friday Social Groups
Cognitive Fitness Alumni Only – Free

Reconnect with friends made in your Cognitive Fitness cohort,
and meet others who have completed the program in a different class.
This is a great way to stay connected and socially engaged.

Location: Perelman Center for Advanced Medicine
3400 Civic Center Boulevard, Philadelphia
10:30 AM – 12:00PM

March 27th  April 24th  May 22nd  June 26th
8-Week Spring Session
March 23 – May 15

This is our core Cognitive Fitness class that meets twice weekly for 8 weeks.
Tuition is $950.

Available in West Philadelphia and Valley Forge

The Aging Brain and Alzheimer’s Disease: Let’s Talk About Your Brain

The Franklin Institute

March 11, 2015
7:30 p.m. – 8:30 p.m.

Join experts in aging and Alzheimer’s disease from the Penn Memory Center for an evening at the Franklin Institute. We’ll discuss the aging brain, Alzheimer’s disease and the impact it has on families and communities.

Presenters include:

John Trojanowski, M.D., Ph.D.
Director of the Institute on Aging and Co-Director, Center for Neurodegenerative Disease Research, University of Pennsylvania

Felicia Greenfield, L.C.S.W.
Associate Director for Clinical and Research Operations, Penn Memory Center, University of Pennsylvania

Staff from the Penn Memory Center will be on hand talk about our programs and services including PENN Care Management (our geriatric care management program), Cognitive Fitness, research opportunities and more.

Ticket Prices:
Free for Franklin Institute members
$5.00 for non-members

For more information, click here. To register for this event, please call 215-448-1200.


The A4 Study is Now Enrolling at the Penn Memory Center

If you are a healthy older adult with normal memory, now is the time to join the fight to prevent Alzheimer’s disease.

The A4 study is a historic clinical trial for older individuals who may be at risk for Alzheimer’s disease (AD). The study aims to prevent the memory loss associated with Alzheimer’s disease (AD).

You can read more about the study and the eligibility requirements at the A4 Study website.


Do you have a passion, talent, or skill that you would like to share with others?

Research tells us that cognitive stimulation and social engagement are key components to successful aging. The Penn Memory Center is pleased to provide a platform for our patients and community to come together and learn from one another. If you would like to volunteer to lead a book club or a discussion group, teach knitting, lead a yoga class, or share another skill with others at the Penn Memory Center, we are happy to host, promote and provide some administrative assistance to transform your interest into action.

Interested volunteers should contact Felicia Greenfield at 215-614-1828 or

News and Events

Tonight, March 11, 2015, is  the night for “The Aging Brain and Alzheimer’s Disease: Let’s Talk About Your Brain” at
Read More

Jason Karlawish, M.D. suggests in the Philadelphia Inquirer on Sunday March 8, 2015 that Still Alice, the bestselling novel and
Read More

Listen live now on Radio Times to Jason Karlawish, associate director of the Penn Memory Center, and a discussion of
Read More

A National Institutes of Health public-private partnership aimed at accelerating Alzheimer’s disease drug development  launched its “Big Data” portal on Wednesday,
Read More

A film documenting the year in the life of a woman with Frontotemporal Degeneration will debut on Tuesday, March 10th
Read More

Penn Memory Center in the Community

Click here to find out about the important work the Penn Memory Center is doing in the Philadelphia community.

 PMC in community

What does it mean to be a caregiver?

Click here to listen to the stories of caregivers from the PMC community.

I am a Caregiver


Questions? Please contact Tigist Hailu, Coordinator for Diversity in Research, at or 215-573-6095.