Research is a chief mission of the Penn Memory Center. We offer a wide range of studies for older adults with memory problems and those with normal cognition. These include:

ADC Logitudinal Research Study

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NACC (pronounced ‘nack’)

The largest, most comprehensive longitudinal (conducted over time) research effort in the US aimed at better understanding AD, MCI, and lifelong brain health.

Those with normal memory and thinking, MCI, or early to moderate AD may be eligible. One visit, running 2-3 hours, annually.

Download a one-page overview of this study including contact information

Diagnostic Studies

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The AVID Study

The purpose of the AVID study is to evaluate the safety and imaging characteristics of an investigational PET imaging agent that binds to a protein called tau. Being able to measure tau protein is of considerable importance for tracking brain changes associated with Alzheimer’s disease.

This new PET tracer has potential application as a marker for assessing disease severity and may be useful in selecting patients for therapy and for monitoring disease progression.

Individuals at least 50 years of age with Mild Cognitive Impairment or Alzheimer’s disease may be eligible for this study.

Download a one-page overview of this study including contact information (for Individuals with Mild Cognitive Impairment or Alzheimer’s disease).

 

 

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The EmPCAD Study

The purpose the EmPCAD study is to develop inexpensive, noninvasive cognitive screening tools which help to detect the earliest signs of Alzheimer’s disease pathology in people before they have symptoms of the disease. This study will evaluate several memory tests in cognitively normal older adults to determine if they are sensitive to evidence of Alzheimer’s disease brain changes based on cerebrospinal fluid (CSF) analysis.

Individuals 60-89 years of age who are cognitively normal may be eligible, and no study partner is required.

The EmPCAD study seeks participants already enrolled in the Penn Memory Center longitudinal cohort of the NACC study or participants who have completed equivalent testing.

 

Download a one-page overview of this study including contact information

 

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The ASL-PET Study

The purpose of the ASL-PET study is to determine the value of a special MRI scan that measures cerebral blood flow (called Arterial Spin Labeled MRI) in the diagnosis of Mild Cognitive Impairment. We will compare this measure with other more established tests: brain imaging with Postiron Emission Tomography (PET/CT) and a lumbar puncture (LP) procedure, which allow researchers to evaluate the quantity of proteins associated with Alzheimer’s Disease.

Individuals 55-89 years of age with a diagnosis of Mild Cognitive Impairment (MCI) or normal controls may be eligible.
Download a one-page overview of the study including contact information

Treatment Trials

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The Toyama Study for Patients with Mild to Moderate Alzheimer’s Disease

The Toyama study will investigate the safety, tolerability and cognitive effects of the T-817MA drug on individuals with mild to moderate Alzheimer’s disease. This drug is not FDA approved and is investigational. Individuals 55 -85 years of age with a diagnosis of probable AD and who have been taking donepezil (Aricept) for at least 6 months may be eligible.

Download a one-page overview of this study including contact information.

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BACE-1 Study for patients with Mild Cognitive Impairment

The Merck BACE-1 Study is a Phase III study for patients with Mild Cognitive Impairment testing the safety, tolerability and cognitive effects of the Merck BACE inhibitor drug. This study is for individuals 50-85 years of age with a diagnosis of mild cognitive impairment.

This drug is not FDA approved and is investigational. As a BACE inhibitor, the drug inhibits the enzyme that produces beta amyloid plaques, deposits of which accumulate in the brains of patients with Alzheimer’s disease. The study will assess the effects of the drug on cognition and the ability to perform everyday activities.

Participants must have a reliable study partner: a spouse, relative, or friend who knows the participant well and sees him or her often, who will attend all study visits, and who will provide information about the participant during the study.

Download a one-page overview of this study including contact information

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The A4 Study

The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study (A4 for short), is a clinical research study for older individuals who may be at risk for Alzheimer’s disease (AD). The A4 study is investigating a drug intervention, solanezumab, and Individuals 65-85 years of age with normal cognition may be eligible. The study requires infusion visits every four weeks, for a total of 42 infusion visits over three consecutive years.

 

Download a one-page overview of this study including contact information

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BACE 1

The Merck BACE 1 study is a Phase II study testing the safety, tolerability, and cognitive effects of the Merck BACE inhibitor drug.

Individuals 55-85 years of age with a diagnosis of mild to moderate Alzheimer’s disease may be eligible. The study includes one baseline visit, 10 in-clinic visits, and 7 phone calls.

Download a one-page overview of the study including contact information

Interview Studies

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Aging Brain and Cognition (ABC) Study

The purpose of the Aging Brain & Cognition (ABC) study is to learn about how the aging brain makes quick decisions. Individuals above the age of 60 with a diagnosis of Alzheimer’s Disease (AD), Mild Cognitive Impairment (MCI), or normal controls, may be eligible to participate. Study activity includes a visit to the clinic at the Penn Memory Center for one 1-hour appointment and completion of several computerized, puzzle-like problems that will take about 1 hour.

Download a one-page overview of this study including contact information.