High Fat Diet Produces Brain Insulin Resistance in Mice

There is growing recognition that insulin resistance, type II diabetes and other features of the metabolic syndrome are associated with brain disorders including Alzheimer’s disease and other neurodegenerative dementias.  In a study led by Steven Arnold, MD, Director of the Penn Memory Center, researchers found that a high fat diet is bad for the brain (at least in mice), causing brain insulin resistance, lower densities of synapses and impaired memory.  The researchers fed mice a very high fat diet for 17 days or a moderate high fat diet for 8 weeks and examined changes in brain insulin signaling responses. You can read the study here.

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